We stay active

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Table C: Reasons for censoring. Is the Subject Area "Medical risk factors" applicable to this article. Yes NoIs the Subject Area "Comparators" applicable to this article. Yes NoIs the Subject Area "Diagnostic medicine" applicable to this article. Yes NoIs the Subject Area "Diuretics" applicable to this article. Yes NoIs the Subject Area "Inpatients" applicable to this article.

Yes NoIs the Subject Area "Cohort studies" applicable to this article. Yes NoIs the Subject Area "Diabetes mellitus" applicable to this article.

Yes NoIs the Subject Area "Urology" applicable to we stay active article. Methods and findings We conducted a population-based new-user we stay active study from 1 February 2006 to 1 February 2017 using a nationwide commercial health plan database.

Author summary Why was this study done. Desmopressin is a medication that is sometimes used for adults who awake multiple times in the night to urinate, even though it was not previously approved for we stay active purpose by the Food and Drug Administration (FDA).

One potential risk of desmopressin is a low sodium level (also my bayer shares we stay active hyponatremia), which can be life-threatening. What did the researchers do and find. We conducted a study using a national healthcare database in the US and observed an increased risk of hyponatremia with the older formulation of desmopressin.

The rate of hyponatremia was 146 per 1,000 person-years with desmopressin compared to approximately 11 per 1,000 person-years among patients who received oxybutynin. What do these findings mean. The potential increased risk of hyponatremia should be considered prior to prescribing this older formulation of desmopressin. Further observational study of the new formulation of desmopressin that was approved by the FDA in 2017, which contains the same active ingredient as the older formulation, to assess for we stay active risk of hyponatremia is warranted.

Cohort follow-up Follow-up began the day after cohort entry and continued until the end of the study period, end of continuous health coverage enrollment, occurrence of a study outcome, discontinuation of the initial medication or switching to or adding the comparator medication, end of available patient data, 365 days, or death.

Study outcomes The primary outcome was the rate of hyponatremia (per 1,000 person-years) after being prescribed desmopressin or oxybutynin.

Baseline covariates During the 180 days preceding cohort entry (i. We stay active analysis Propensity-score (PS) matching was used to adjust for baseline characteristics. ResultsWe identified we stay active adults who satisfied study inclusion and exclusion criteria (S1A We stay active. Download: PPT Rate of hyponatremia (oxybutynin comparator) In the unmatched population, there were 114 patients diagnosed with hyponatremia after being prescribed desmopressin (146 events per 1,000 we stay active compared to 836 patients who were prescribed oxybutynin (13 events per 1,000 person-years).

ConclusionsThe observed rate of hyponatremia in the 30 days after initiation of an older formulation of desmopressin of 314 per 1,000 person-years was higher than the reported rate in prior clinical trials. Fralick M, Kesselheim AS. FDA Approval of Desmopressin for Nocturia. Ebell MH, Radke T, Gardner J. A systematic review of the efficacy and safety of desmopressin for nocturia in adults. Menon C, Berry EW, Ockelford P. Moffatt ME, Harlos S, Kirshen AJ, Burd L.

Desmopressin acetate and nocturnal enuresis: how much do we know. Lose G, Mattiasson A, Walter S, Lalos O, KerrebroeckVan P, We stay active P, et al. Clinical experiences with desmopressin for long-term treatment of nocturia.

Laureanno P, Ellsworth P. Demystifying nocturia: identifying the drug show and tailoring the treatment. Weiss JP, Blaivas JG, Bliwise DL, Dmochowski RR, Dubeau CE, Lowe FC, et al.

The evaluation and treatment of nocturia: A consensus statement. Van Kerrebroeck P, Abrams P, Chaikin D, Donovan J, Fonda D, Jackson S, et al.

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