Global ecology and conservation

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Selected ethical issues included in the Ottawa Statement on the Ethical Design and Conduct of Cluster Randomised Trials that are relevant to implementation trials.

Adapted from Taljaard et al, 2013134The Standards for Reporting Implementation Studies (StARI) guide has been designed specifically to facilitate the better reporting of implementation trials and should be used in conjunction with the Global ecology and conservation reporting guideline (and extension) specific to the type of randomised trial design used. High quality randomised trials have a key role in advancing implementation science by providing robust evidence on the effects of approaches to improve the uptake and integration of evidence based practice.

With the emergence of more accepted concepts, terminology, processes, and reporting standards in the field, the opportunity to improve the development, conduct, and reporting of such trials is considerable. The development of guidance documents have proved a useful resource in improving the rigour of randomised controlled trials in healthcare and public health. Contributors: The manuscript was the product of brown johnson collective contribution of a broad multidisciplinary team.

All authors are experienced health services and public health researchers. Additionally the author team include those with expertise in implementation science (LW, RF, JP, JMG, NMI, Global ecology and conservation, SLY), behavioural science (JP, JW, RKH), randomised trial methods (JMG, JP, MT, NMI, RF, CMW), research ethics (MT, JMG), the application of theory (JP, BJP), biostatistics (MT) and research reporting (JMG, MT). The team also included a range of health policy makers and practitioners (RS, NN, JW, MK, AM, RKH).

The guidance draws on this expertise and Theophylline 5% Dextrose Injection Viaflex (Theophylline Anhydrous Injection Viaflex)- FDA range of seminal randomised trial methods texts, and recent developments in implementation science methods and conventions and standards. All authors contributed to the planning of manuscript, participated in meetings to develop content, and provided critical manuscript edits and comments on drafts.

The drafting of the plate was led by LW. LW is the guarantor. Funding: No specific funding was received for this work. LW receives salary support from an Australian National Health and Medical Research Council (NHMRC) career development fellowship (grant APP1128348) and Heart Foundation Future Leader Fellowship (grant 101175). NMI holds a Canada Research chair (tier 2) in implementation global ecology and conservation evidence-based practice and a clinician scholar award from the Department of Family and Community Medicine, University of Toronto, Toronto, Canada.

JMG holds a Canada Research chair in health knowledge transfer and uptake and a Canadian Institutes of Health Research Foundation grant (FDN 143269). BJP was supported by the United States National Institute of Mental Health (K01MH113806).

CMW was supported by the NHMRC of Australia (APP1177226). RS was supported by an NHMRC TRIP fellowship (APP1150661). RKH was supported by NHMRC early career research fellowship (APP1160419). SLY is supported by a Discovery Early Career Researcher Aware grant from the Australian Research Council (DE170100382). Patient and public involvement: Patients and the public were not involved during the process of this research.

Respond to this articleRegister for alerts If you have registered for alerts, you should use your registered email address as your username Citation toolsDownload global ecology and conservation article to citation manager View ORCID ProfileLuke Wolfenden associate professor, Robbie Foy professor, Justin Presseau associate professor, Jeremy M Global ecology and conservation senior scientist and professor, Noah M Ivers associate professor, Byron J Powell assistant professor et al Wolfenden L, Foy R, Presseau J, Grimshaw J M, Ivers N M, Powell B J et al.

Table 1 Definitions of key terms in implementation scienceView this table:View popupView inlineSummary pointsCriticisms of current implementation trials include risks of bias, lack of theory use, lack of standardised terminology to describe implementation strategies, and limited measures and poor reportingThis article consolidates recent methodological developments in implementation science with established guidance from seminal texts of randomised trial methods to provide best practice guidance to improve the development and conduct of randomised implementation trialsConsideration of such guidance will improve the quality and use of randomised implementation trials for healthcare and test crp health improvementRecommendations for the development, conduct, and reporting of randomised implementation trialsWhen is an implementation trial warranted.

Implementation trials generate scientific knowledge to improve the uptake of evidence based interventions in global ecology and conservation. The need for a trial and the trial methods used should also be guided Cenobamate Tablets (Xcopri)- FDA the needs, values, and input of end users and other stakeholder groups.

Table 2 Typical characteristics of conventional clinical or public health trials, effectiveness-implementation global ecology and conservation trials, and implementation trials. Adapted from Curran et al, 2012, with permission25View this table:View popupView inlineRecruitment and retentionImplementation trials usually recruit and randomise staff or organisations rather than individual patients.

Underlying trial philosophy: pragmatic and explanatory trialsExplanatory trials use methods that prioritise internal validity, and are undertaken in more ideal research conditions. Table 3 Description and key considerations of randomised designs for assessing the effects of implementation interventionsView this table:View popupView inlineLevel of randomisationIn an individually randomised trial, individual participants (that is, patients)55 are randomised to one of two or more global ecology and conservation groups, and outcomes (eg, clinical effectiveness) are measured at the same level as the unit of randomisation (patient).

Parallel, two arm, randomised trialParallel, two arm, randomised global ecology and conservation trials compare the effects of an implementation strategy with those of a control or global ecology and conservation implementation strategy. Hybrid trialsHybrid trials can use any type of randomised trial design.



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