Valvular heart disease

Valvular heart disease advise

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Antihypertensive efficacy and safety of felodipine compared with nitrendipine in mild to moderate hypertension. Elliott WJ, Montoro R, Smith D, et al. Comparison of two strategies for intensifying antihypertensive treatment.

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The felodipine Valvular heart disease in the elderly versus young working group. Trachtman H, Frank R, Mahan JD, et al. Clinical trial valvular heart disease extended-release felodipine in pediatric essential hypertension. Falkner B, Daniels SR. Summary of the fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents.

Hardy B, Bartle W, Myers M, et al. Effect of indomethacin on the valvular heart disease and pharmacodynamics of felodipine. Dunselman P, Edgar B, Scaf A, et al. Pharmacokinetics of felodipine after intravenous and chronic oral administration in patients with congestive heart failure. Carruthers S, Vint-Reed C. Antihypertensive effect and tolerability of felodipine extended release (ER) tablets in comparison with felodipine plain tablets (PT) and placebo in hypertensives on a diuretic.

Cheung BM, Lau C-P, Wu B-Z. Amlodipine, felodipine, and isradipine in the treatment of chinese patients with mild-to-moderate hypertension. In both T1DM and T2DM, there is accelerated gastric emptying and postprandial hyperglucagonemia.

Furthermore, insulin therapy itself is associated with risk of hypoglycemia and weight-gain both of which are barriers to achieving good control. A synthetic amylin analogue, pramlintide is a drug with above mentioned properties. Other medications with similar properties are glucagon-like peptide-1 receptor agonists (GLP-1 RAs). Newer GLP-1RA, semaglutide has shown a robust reduction in HbA1c up to 1. However, individual differences exist between the different GLP-1RAs, in terms of efficacy, pharmacokinetics, tolerability, and vascular protection.

The potential of vascular protection offered by newer anti-diabetic agents has generated a lot of excitement in the field of diabetes, and to a large extent, is now driving treatment decisions.

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